Targeted Protein Degradation Market Size Worth USD 3547.91 million by 2034 | CAGR: 20.7%

The global targeted protein degradation market size is expected to reach USD 3547.91 million by 2034, according to a new study by Polaris Market Research. The report “Targeted Protein Degradation Market Size, Share, Trends, Industry Analysis Report: By Type, Therapeutic Area (Inflammatory Disorders, Neurological Disorders, Oncological Disorders, Respiratory Disorders, and Others), Route of Administration, and Region (North America, Europe, Asia Pacific, Latin America, and Middle East & Africa) – Market Forecast, 2025–2034” gives a detailed insight into current market dynamics and provides analysis on future market growth.

The targeted protein degradation (TPD) market is experiencing significant growth, driven by advances in precision medicine and increased investments in biotechnology. A key driver is the potential of TPD to target previously "undruggable" proteins, opening new therapeutic avenues for complex diseases such as cancer and neurodegenerative disorders.

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Opportunities in this market are expected to rise during the forecast period as pharmaceutical companies collaborate with academic institutions and tech firms to develop novel degraders. The emerging trend toward personalized medicine and the growing focus on small-molecule therapeutics also fuel market demand. Overall, with increasing research activities and clinical trials, the TPD market is poised for rapid expansion.

Targeted Protein Degradation Market Report Highlights:

• Based on type, the proteolysis-targeting chimeric molecules (PROTACs) segment dominates the market, being widely adopted due to their ability to degrade a broad range of proteins. Degronimids are expected to witness rapid growth, driven by advancements in small-molecule therapeutics.
• In terms of therapeutic area, the oncological disorders segment holds the largest share, as cancer treatments heavily rely on targeted protein degradation. The neurological disorders segment is projected to grow rapidly, with increasing research on neurodegenerative diseases such as Alzheimer's.
• By route of administration, the intravenous segment dominates the market; the IV route is especially used for therapies requiring direct and controlled delivery.
• North America leads the TPD market, owing to strong R&D activities and pharmaceutical investments. Asia Pacific is the fastest-growing region, driven by rising healthcare expenditure, growing biotechnology sectors, and an increasing focus on innovative therapies.
• Some of the key players in the market are Arvinas, Kymera Therapeutics, and Nurix Therapeutics.

Polaris Market Research has segmented the targeted protein degradation market report on the basis of type, therapeutic area, route of administration, and region:

By Type Outlook (Revenue – USD Million, 2020–2034)

• Degronimids
• Immunomodulatory Drugs (IMiDs)
• Proteolysis-Targeting Chimeric Molecules (PROTACs)
• Sudden Acquired Retinal Degeneration Syndrome (SARDs)
• Selective Estrogen Receptor Degraders (SERDs)
• Others

By Therapeutic Area Outlook (Revenue – USD Million, 2020–2034)

• Inflammatory Disorders
• Neurological Disorders
• Oncological Disorders
• Respiratory Disorders
• Others

By Route of Administration Outlook (Revenue – USD Million, 2020–2034)

• Oral
• Intravenous
• Others

By Regional Outlook (Revenue – USD Million, 2020–2034)

• North America
  • US
  • Canada
• Europe
  • Germany
  • France
  • UK
  • Italy
  • Spain
  • Netherlands
  • Russia
  • Rest of Europe
• Asia Pacific
  • China
  •  Japan
  •  India
  •  Malaysia
  •  South Korea
  • Indonesia
  • Australia
  • Vietnam
  • Rest of Asia Pacific
• Middle East & Africa
  • Saudi Arabia
  • UAE
  • Israel
  • South Africa
  • Rest of Middle East & Africa
• Latin America
  • Mexico
  • Brazil
  • Argentina
  • Rest of Latin America

Targeted Protein Degradation Market Report Scope